In this episode of the InSiGHT into Research Podcast, Dr Sonia Kupfer and Dr Benjamin Zare speak with Prof Sir John Burn about the landmark CaPP3 trial and its first results on using aspirin to prevent cancer in people with Lynch syndrome. They discuss what the study tells us about aspirin dose, cancer prevention, side effects, and what these findings could mean for clinical practice.

Hosts Dr Sonia Kupfer (University of Chicago Medical Center, Chicago) and Dr Benjamin Zare (St Mark’s Hospital, London) discuss Prevalence and Consequences of APC Mosaicism in Patients With Colorectal Adenomas, published in Gastroenterology in June 2026 with authors Dr Diantha Terlouw and Dr Maartje Nielsen (Leiden University Medical Center, Netherlands). Explores testing, missing mosaic variants, surveillance...